Dr. Prabhat Ranjan
Post doctoral researcher (Marie Skłodowska-Curie fellow, PF-2021)
Room: 200.3.049
Email: p.ranjan@maastrichtuniversity.nl 
LinkedIn: https://www.linkedin.com/in/prabhat-ranjan-418117141/
ORCID: https://orcid.org/0000-0002-4038-6142

 

Research interests

Prabhat’s research focuses on the development of new photochemical transformation, visible light mediated multicomponent reactions employing flow chemistry and transition metal catalysis.

 A New Light on Isocyanide Synthesis (HORIZON-MSCA-2021)

The aim of this project is to accomplish an economically viable and ecofriendly large scale synthesis of this fundamental and highly versatile building block that has already found widespread appreciation in academia, but suffers from underutilization in the pharma-, fine-chemicals and materials industry. The most common route to access isocyanides is the dehydration of formamides using various dehydrating agents, like the combination of triethylamine and POCl3/Burgess’s reagent/cyanuric chloride/triflic anhydride/p-tosyl chloride. Even though a wide number of synthetic procedures for isocyanide preparation have been devised over the years, these methodologies still hold a number of challenges outlined below.

List of Publications

  1. Ranjan, P.; Pillitteri, S.; Coppola, G.; Oliva, M.; Van der Eycken, E.V.; Sharma, U. K.* Unlocking the accessibility of alkyl radicals from boronic acids through hydrogen-bond assisted organophotoredox activation. ACS Catalysis 2021, 11, 10862.
  2. Ranjan, P.; Oliva, M.; Pillitteri, S.; Coppola, G.; Van der Eycken, E.V.; Sharma, U.K.* Photoredox-catalyzed multicomponent Petasis reaction in batch and continuous flow with alkyl boronic acid. iscience 2021, 24, 103134.
  3. Ranjan, P.; Manno, R.; Sebastian, V.*; Mallada, R.; Irusta, S.; Sharma, U. K.; Van der Eycken, E. V.*; Santamaria, J. Continuous Microwave-Assisted Synthesis of Silver Nanoclusters Confined in Mesoporous SBA-15: Application in Alkyne Cyclizations. Mater. 2020, 32, 2874.
  4. Ranjan, P.; Ojeda, G. M.; Sharma, U. K.*; Van der Eycken, E. V.* Metal-Free Dearomatization: Direct Access to Spiroindol(en)ines in Batch and Continuous-Flow. A Eur. J. 2019, 25, 244