128. Shining light on tryptamine-derived isocyanides: access to constrained spirocylic scaffolds
Wu, M.; Saya, J. M.; Han, P.; Walia, R.; Pradhan, B.; Honing, M.; Ranjan, P.*; Orru, R. V.A.* Chem. Sci. 2024, Advance article.
127. Dearomative Spirocyclization of Tryptamine-Derived Isocyanides via Iron-Catalyzed Carbene Transfer
Roose, T. R.; McSorley, F.; Groenhuijzen, B.; Saya, J. M.; Maes, B. U.; Orru, R. V. A.; Ruijter, E. J. Org. Chem. 2023, 88, 17345-17355.
126. A Cobalt Mediated Nitrene Transfer aza-Wittig Cascade Reaction To Access 1,3,4-Oxadiazole Scaffolds.
Verdoorn, D. S.; Ranjan, P.; De Reuver, T.; Janssen, E.; Vande Velde, C. M. L.; Saya, J. M.; Maes, B. U. W.; Orru, R. V. A. Org Lett 2023, 25, 4005-4009.
125.Iron-Catalysed Carbene Transfer to Isocyanides as a Platform for Heterocycle Synthesis.
Roose, T. R.; Preschel, H. D.; Tejedor, H. M.; Roozee, J. C.; Hamlin, T. A.; Maes, B. U. W.; Ruijter, E.; Orru, R. V. A. Chem. Eur. J. 2023, 29, e202203074.
124. Transition metal-catalysed carbene- and nitrene transfer to carbon monoxide and isocyanides
Roose, T. R.; Verdoorn, D. S.; Mampuys, P.; Ruijter, E.; Maes, B. U.; Orru, R. V. A. Chem. Soc. Rev. 2022, 51, 5842-5877.
123.Synthesis of Heterocycles via Aerobic Ni-Catalyzed Imidoylation of Aromatic 1,2-Bis-nucleophiles with Isocyanides
Escudero, J.; Mampuys, P.; Mensch, C.; Bheeter, C. B.; Vroemans, R.; Orru, R. V. A.; Harvey, J.; Maes, B. U. W. ACS Cat. 2022, 12, 6857-6873.
122. Expanding the radiochemist’s toolbox: carbon-11 labelled formamides and isocyanides for PET tracer synthesis
Bonnemaire, C.; Windhorst, A. D.; Van der Aa, F.; Collet, J.; Roose, T.; Ruijter, E.; Orru, R. V. A.; Vugts, D. Nucl. Med. Biol. 2021, 96-97, S1–S107.
121. Post-Modification of Biobased Pyrazines and Their Polyesters
Würdemann M. A.; Faber, T.; Harings, J. A.; Bernaerts, K. V.; Orru, R. V. A.; Pich, A. Macromolecules 2021, 54, 10850-10859.
120. Synthesis of Densely Functionalized Pyrimidouracils by Nickel(II)-Catalyzed Isocyanide Insertion
Collet, J. W.; Morel, B.; Lin, H. C.; Roose, T. R.; Mampuys, P.; Orru R. V. A.; Ruijter, E.; Maes, B. U. Org. Lett. 2020, 22, 914-919.
119. Base Metal Catalyzed Isocyanide Insertions
Collet, J. W.; Roose, T. R.; Ruijter, E.; Maes, B. U.; Orru, R. V. A. Angew. Chem., Int. Ed. Engl. 2020, 2, 540-558.
118. Zinc(II)-mediated diastereoselective Passerini reactions of biocatalytically desymmetrised renewable inputs
Moni, L.; Banfi, L.; Cartagenova, D.; Cavalli, A.; Lambruschini, C.; Martino, E.; Orru, R. V. A.; Ruijter, E.; Saya, J. M.; Sgrignani, J.; Riva, R. Org. Chem. Front. 2020, 7, 380-398.
117. Synthesis of Quinazolin-4-ones by Copper-Catalyzed Isocyanide Insertion
Collet, J. W.; Van Der Nol, E. A.; Roose, T. R.; Maes, B. U.; Ruijter, E.; Orru, R. V. A. J. Org. Chem. 2020, 85, 11, 7378–7385.
116. The Forgotten Pyrazines: Exploring the Dakin-West Reaction
Wüdemann, M. A.; Niţu, C.; Wildeman, S. M.; Bernaerts, K. V.; Orru, R. V. A. Chem. Eur. J. 2020, 26, 8090-8100.
115. In Situ Cyclization of Proteins (INCYPRO): Crosslink Derivatization Fine-Tunes Protein Stability
Neubacher, S.; Saya, J. M.; Amore, A.; Grossmann. T. N. J. Org. Chem. 2020, 85, 1476−1483.
114. Stereoselective Chemoenzymatic Cascade Synthesis of the bis-THF Core of Acetogenins
Van Lint, M. J.; Hall, M.; Faber, K.; van Spanning, R. J.; Ruijter, E.; Orru, R. V. A. Eur. J. Org. Chem. 2019, 1092–1101.
113. Total Synthesis of Aspidosperma and Strychnos Alkaloids through Indole Dearomatization
Saya. J. M.; Ruijter, E.; Orru, R. V. A. Chem. Eur. J. 2019, 25, 8916-8935.
112. Mild and Practical Indole C2 Allylation by Allylboration of in situ Generated 3-Chloroindolenines
Saya, J. M.; van Wordragen, E. D.; Orru, R. V. A.; Ruijter, E. Eur. J. Org. Chem. 2019, 5156–5160.
111. Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides
van der Heijden, G.; van Schaik, T. B.; Mouarrawis, V.; de Wit, M. J.; Velde, C. M.; Ruijter, E.; Orru, R. V. A. Eur. J. Org. Chem. 2019, 5313-5325.
110. Integrative Theory/Experiment-Driven Exploration of a Multicomponent Reaction towards Imidazoline-2-(thi)ones
Kruithof, A.; Mulder, J. R.; Ruiz, J. M.; Janssen, E.; Mooijman, M.; Ruijter, E.; Guerra, C. F.; Bickelhaupt, F. M.; Orru, R. V. A. Eur. J. Org. Chem. 2018, 104-112.
109. Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade
Collet, J. W.; Ackermans, K.; Lambregts, J.; Maes, B. U.; Orru, R. V. A.; Ruijter, E. J. Org. Chem. 2018, 83, 854–861.
108. Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines
Rainoldi, G.; Begnini, F.; De Munnik, M.; Lo Presti, L.; Vande Velde, C. M.; Orru, R. V. A.; Lesma, G.; Ruijter, E.; Silvani, A. ACS Comb. Sci. 2018, 20, 98–105.
107. Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols
Saya, J. M.; Berabez, R.; Broersen, P.; Schuringa, I.; Kruithof, A.; Orru, R. V. A.; Ruijter, E. Org. Lett. 2018, 20, 3988–3991.
106. Synthesis of Secondary Amides from Thiocarbamates
Mampuys, P.; Ruijter, E.; Orru, R. V. A.; Maes, B. U. Org. Lett. 2018, 20, 4235–4239.
105. Stereoselective Synthesis of Fused Vinylcyclopropanes by Intramolecular Tsuji-Trost Cascade Cyclization
Braun, J.; Ariëns, M. I.; Matsuo, B. T.; De Vries, S.; Van Wordragen, E. D.; Ellenbroek, B. D.; Vande Velde, C. M.; Orru R. V. A.; Ruijter, E. Org. Lett. 2018, 20, 6611–6615.
104. Iodospirocyclization of Tryptamine-Derived Isocyanides: Formal Total Synthesis of Aspidofractinine
Saya, J. M.; Roose, T. R.; Peek, J. J.; Weijers, B.; de Waal, T. J.; Vande Velde, C. M.; Orru, R. V. A.; Ruijter, E. Angew. Chem., Int. Ed. Engl. 2018, 57, 15232-15236.
103. Multicomponent reactions in drug discovery and medicinal chemistry
Ruijter, E.; Orru, R.; Drug Discov. Today Technol. 2018, 29, 1-2.
102. Fluorine-18 labelled building blocks for PET tracer synthesis
van der Born, D.; Pees, A.; Poot, A. J.; Orru, R. V. A.; Windhorst, A. D.; Vugts, D. J. Chem. Soc. Rev. 2017, 46, 4709-4773.
101. Biocatalytic access to nonracemic γ-oxo esters via stereoselective reduction using ene-reductases
Turrini, N. G.; Cioc, R. C.; van der Niet, D. J.; Ruijter, E.; Orru, R. V. A.; Hall, M.; Faber, K. Green Chem. 2017, 19, 511-518.
100. Ugi-Type Reactions of Spirocyclic Indolenines as a Platform for Compound Library Generation
Estévez, V.; Kloeters, L.; Kwietniewska, N.; Vicente-Garcia, E.; Ruijter, E.; Orru, R. V. A. Synlett 2017, 28, 376-380.
99. Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids
Cioc, R. C.; Estevez, V.; van der Niet, D. J.; Vande Velde, C. M.; Turrini, N. G.; Hall, M.; Faber, K.; Ruijter, E.; Orru, R. V. A. Eur. J. Org. Chem. 2017, 1262–1271.
98. A Hybrid Solid-State NMR and Electron Microscopy Structure-Determination Protocol for Engineering Advanced para-Crystalline Optical Materials
Thomas, B.; Rombouts, J.; Oostergetel, G. T.; Gupta, K. B.; Buda, F.; Lammertsma, K.; Orru, R. V. A.; de Groot, H. J. Chem. Eur. J. 2017, 23, 3280–3284.
97. Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams
Cioc, R. C.; van Riempst, L. S.; Schuckman, P.; Ruijter, E.; Orru, R. V. A. Synthesis 2017, 49, 1664-1674.
96. Thiazine-2-thiones as Masked 1-Azadienes in Cascade Dimerization Reactions
Kruithof, A.; Velde, C. M.; Ruijter, E.; Orru R. V. A. Molecules 2017, 22, 541.
95. Determination of Controlled Self-Assembly of a Paracrystalline Material by Homology Modelling with Hybrid NMR and TEM
Thomas, B.; Rombouts, J.; Gupta, K. B.; Orru, R. V. A.; Lammertsma, K.; de Groot, H. J. Chem. Eur. J. 2017, 23, 9346–9351.
94. Combining Isocyanides with Carbon Dioxide in Palladium-Catalyzed Heterocycle Synthesis: N3-Substituted Quinazoline-2,4(1H,3H)-diones via a Three-Component Reaction
Mampuys, P.; Neumann, H.; Sergeyev, S.; Orru, R. V. A.; Jiao, H.; Spannenberg, A.; Maes, B. U.; Beller, M. ACS Catal. 2017, 7, 5549–5556.
93. Copper(i) catalyzed oxidative hydrolysis of Ugi 3-component and Ugi-azide reaction products towards 2° α-ketoamides and α-ketotetrazoles
Collet, J. W.; Foley, C.; Shaw, A. Y.; Orru, R. V. A.; Ruijter, E.; Hulme, C. Org. Biomol. Chem. 2017, 15, 6132-6135.
92. Trityl isocyanide as a mechanistic probe in multicomponent chemistry: Walking the line between Ugi- and Strecker-type reactions
Cioc, R. C.; Preschel, H. D.; van der Heijden, G.; Ruijter, E.; Orru, R. V. A. Chem. Eur. J. 2017, 22, 7837-7842.
91. Synthesis, characterization and biological acitvity of fluorescently labeled bedaquiline analogues
Rombouts, J. A.; Veenboer, R. M.; Villellas, C.; Lu, P.; Ehlers, A. W.; Andries, K.; Koul, A.; Lill, H.; Ruijter, E.; Orru, R. V. A.; Lammertsma, K.; Bald, D.; Slootweg, J. C. RSC Adv. 2016, 6, 108708-108716.
90. Synthesis of polycyclic spiroindolines by highly diastereoselective interrupted Ugi cascade reactions of 3-(2-isocyanoethyl)indoles
Saya, J. M.; Oppelaar, B.; Cioc, R. C.; van der Heijden, G.; Vandevelde, C. M.; Orru, R. V. A.; Ruijter, E. Chem. Commun. 2016, 52, 12482-12485.
89. Stereoselective monoamine oxidase-catalyzed oxidative Aza-Friedel-Crafts reactions of mesopyrrolidines in aqueous buffer
de Graaff, C.; Oppelaar, B.; Peruch, O.; Vandervelde, C. M.; Bechi, B.; Turner, N. J.; Ruijter, E.; Orru, R. V. A. Adv. Synth. Catal. 2016, 358, 1555-1560.
88. Nickel-based dye-sensitized photocathode towards proton reduction using a molecular nickel catalyst and an organic dye
van den Bosch, B.; Rombouts, J. A.; Orru, R. V. A.; Reek J. N.; Detz, R. J. ChemCatChem 2016, 8, 1392-1398.
87. Metal-free one-pot alpha-carboxylation of primary alcohols
van der Heijden, G.; Kraakman, J.; Biemolt, J.; Ruijter, E.; Orru, R. V. A. Org. Biomol. Chem. 2016, 14, 9716-9719.
86. Iodide-catalyzed synthesis of secondary thiocarbamates from isocyanides and thiosulfonates
Mampuys, P.; Zhu, Y.; Sergeyev, S.; Ruijter, E.; Orru, R. V. A. Org. Lett. 2016, 18, 2808–2811.
85. Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanide
Cioc, R. C.; Schuckman, P.; Preschel, H. D.; Vlaar, T.; Ruijter, E.; Orru, R. V. A. Org. Lett. 2016, 18, 3562-3565.
84. 2-bromo-6-isocyanopyridine as a universal convertible isocyanide for multicomponent chemistry
van der Heijden, G.; Jong, J. A.; Ruijter, E.; Orru, R. V. A. Org. Lett. 2016, 18, 984–987.
83. Palladium-Catalyzed Construction of Amidines from Arylboronic Acids under Oxidative Conditions
Zhu, F.; Li, Y.; Wang, Z.; Orru, R. V. A.; Maes, B. U.; Wu, X. F. Chem. Eur. J. 2016, 22, 7743-7746.
82. Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids
Zhu, Y. P.; Sergeyev, S.; Franck, P.; Orru, R. V. A.; Maes, B. U. Org. Lett. 2016, 18, 4602–4605.
81. Stereoselective synthesis of fluorinated aminoglycosyl phosphonates
Bouwman, S.; Orru, R. V. A.; Ruijter, E. Org. Biomol. Chem., 2015, 13, 1317-1321.
80. IBX-mediated oxidation of unactivated cyclic amines: application in highly diastereoselective oxidative Ugi-type and aza-Friedel-Crafts reactions
de Graaff, C.; Bensch, L.; van Lint, M. J.; Ruijter, E.; Orru, R. V. A. Org. Biomol. Chem. 2015, 13, 10108-10112.
79. Synthesis of Heterocycles by Formal Cycloadditions of Isocyanides
Kruithof, A.; Ruijter, E.; Orru, R. V. Chem. Asian J. 2015, 10, 508-520.
78. One-Pot Synthesis of N-Substituted β-Amino Alcohols from Aldehydes and Isocyanides
Cioc, R. C.; van der Niet, D. J.; Janssen, E.; Ruijter, E.; Orru, R. V. A. Chem. Eur. J. 2015, 21, 7808-7813.
77. Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction
de Graaff, C.; Bensch, L.; Boersma, S. J.; Cioc, R. C.; van Lint M. J.; Janssen, E.; Turner, N. J.; Orru, R. V. A.; Ruijter, E. Angew. Chem., Int. Ed. Engl. 2015, 54, 14133-14136.
76. Synthesis and Photophysics of a Red-Light Absorbing Supramolecular Chromophore System
Rombouts, J. A.; Ravensbergen, J.; Frese, R. N.; Kennis, J. T.; Ehlers, A. W.; Slootweg, J. C.; Ruijter, E.; Lammertsma, K.; Orru, R. V. A. Chem. Eur. J. 2014, 20, 285-10291.
75. Stereoselective Synthesis of β-Sulfinylamino Isocyanides and 2-Imidazolines
Janssen, G. V.; Vincente-Garcia, E.; Vogels, W.; Slootweg, J. C.; Ruijter. E.; Lammertsma, K.; Orru, R. V. A. Eur. J. Org. Chem. 2014, 3762-3766.
74. Multicomponent reactions: advanced tools for sustainable organic synthesis
Cioc, R. C.; Ruijter, E.; Orru, R. V. A. Green Chem. 2014, 16, 2958-2975.
73. Diastereoselective One-pot Synthesis of Tetra-Functionalized 2-Imidazolines
Janssen, G. V.; Slobbe, P.; Mooijman, M.; Kruithof, A.; Ehlers, A. W.; Fonseca Guerra, C.; Bickelhaupt, F. M.; Slootweg, J. C.; Ruijter, E.; Lammertsma, K.; Orru, R. V. A. J. Org. Chem. 2014, 79, 5219–5226.
72. A Universal Procedure for the [18F]Trifluoromethylation of Aryl Iodides and Aryl Boronic Acids with Highly Improved Specific Activity
van der Born, D.; Sewing, C.; Herscheid, J. D.; Windhorst, A. D.; Orru, R. V. A.; Vugts, D. J. Angew. Chem., Int. Ed. Engl. 2014, 53, 11046-11050.
71. Synthesis of Pyridopyrimidines by Palladium-Catalyzed Isocyanide Insertion
Estévez, V.; Van Baelen, G.; Lentferink, B. H.; Vlaar, T.; Janssen, E.; Maes, B. U.; Orru, R. V. A.; Ruijter, E. ACS Catal. 2014, 4, 40–43.
70. Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics
Koopmanschap, G.; Ruijter, E.; Orru, R. V. A. Beilstein J. Org. Chem. 2014, 10, 544–598.
69. Synthesis of Diverse Azolo[c]quinazolines by Palladium(II)- Catalyzed Aerobic Oxidative Insertion of Isocyanides
Vlaar, T.; Bensch, L.; Kraakman, J.; Vande Velde, C. M.; Maes, B. U.; Orru, R. V. A.; Ruijter, E. Adv. Synth. Catal. 2014, 356, 1205-1209.
68. Synthesis and Photophysics of a Red-Light Absorbing Supramolecular Chromophore System
Rombouts, J. A.; Ravensbergen, J.; Frese, R. N.; Kennis, J. T.; Ehlers, A. W.; Slootweg, J. C.; Ruijter, E.; Lammertsma, K.; Orru, R. V. A. Chem. Eur. J. 2014, 20, 10185-10185.
67. Chemoselective addition of isocyanides to N-tert-butanesulfinimines
Janssen, G. V.; Janssen, E.; Vande Velde C. M.; Ehlers, A. W.; Slootweg, J. C.; Ruijter, E.; Lammertsma, K.; Orru, R. V. A. Org. Lett. 2014, 16, 5116–5119.
66. Sustainable Three-Component Synthesis of Isothioureas from Isocyanides, Thiosulfonates, and Amines
Mampuys, P.; Zhu, Y.; Vlaar, T.; Ruijter, E.; Orru, R. V. A.; Maes B. U. Angew. Chem., Int. Ed. Engl. 2014, 126, 13063-13068.
65. Synthesis of 4-aminoquinolines by aerobic oxidative palladium-catalyzed double C-H activation and isocyanide insertion
Vlaar, T.; Maes, B. U.; Ruijter, E.; Orru, R. V. A. Chem. Heterocycl. Compd. 2013, 49, 902–908.
64. Palladium-Catalyzed Synthesis of 2-Aminobenzoxazinones by Aerobic Oxidative Coupling of Anthranilic Acids and Isocyanides
Vlaar, T.; Orru, R. V. A.; Maes, B. U.; Ruijter, E. J. Org. Chem. 2013, 78, 10469–10475.
63. Palladium-Catalyzed Migratory Insertion of Isocyanides: An Emerging Platform in Cross-Coupling Chemistry
Vlaar, T.; Ruijter, E.; Maes, B. U.; Orru, R. V. A. Angew. Chem. Int. Ed. 2013, 52, 7084–7097.
62. Multicomponent reactions – opportunities for the pharmaceutical industry
Ruijter, E.; Orru, R. V. A. Drug Discov. Today Technol. 2013, 10, e15-e20.
61. Multicomponent Synthesis of 4-Aminophthalazin-1(2H)-ones by Palladium-Catalyzed Isocyanide Insertion
Vlaar, T.; Mampuys, P.; Helliwell, M.; Maes, B. U.; Orru, R. V. A.; Ruijter, E. J. Org. Chem. 2013, 78, 6735–6745.
60. Efficient synthesis of [F-18] trifluoromethane and its application in the synthesis of PET tracers
van der Born, D.; Herscheid, J. D.; Orru, R. V. A.; Vugts, D. J. Chem. Commun., 2013, 49, 4018-4020.
59. Efficiency, Diversity, and Complexity with Multicomponent Reactions
van der Heijden, G.; Ruijter, E.; Orru, R. V. A. Synlett 2013, 24, 0666–0685.
58. Synthesis of Imidazolidine-2-(thi)ones via C2-Selective Oxidation and Thionation of 2-Imidazolinium Halide
Mooijman, M.; Bon, R. S.; Sprenkels, N. E.; Oosterhout, H. N.; de Kanter, F. J.; Groen, M. B.; Ruijter, E.; Orru, R. V. A. Synlett 2012, 23, 80–84.
57. Sustainable Synthesis of Diverse Privileged Heterocycles by Palladium-Catalyzed Aerobic Oxidative Isocyanide Insertion
Vlaar, T.; Cioc, R. C.; Mampuys, P.; Maes, B. U.; Orru, R. V. A.; Ruijter, E. Angew. Chem. Int. Ed. 2012, 51, 13058 –13061.
56. Recent developments in asymmetric multicomponent reactions
de Graaff, C.; Ruijter, E.; Orru, R. V. A. Chem. Soc. Rev. 2012, 41, 3969-4009.
55. Recent applications of multicomponent reactions in medicinal chemistry
Slobbe, P.; Ruijter, E.; Orru, R. V. A. Med. Chem. Commun. 2012, 3, 1189-1218.
54. Concise synthesis of highly substituted benzo[a]quinolizines by a multicomponent reaction/allylation/heck reaction sequence
Den Heeten, R.; Van Der Boon, L. J.; Broere, D. L.; Janssen E.; De Kanter, F. J.; Ruijter, E.; Orru, R. V. A. Eur. J. Org. Chem. 2012, 275–280.
53. Stereoselective synthesis of N-aryl proline amides by biotransformation-Ugi-Smiles sequence
Znabet, A.; Blanken, S.; Janssen, E.; de Kanter, F. J.; Helliwell, M.; Turner, N. J.; Ruijter, E.; Orru, R. V. A. Org. Biomol. Chem. 2012, 10, 941-944.
52. Multicomponent Synthesis of 3,6-Dihydro-2H-1,3-thiazine-2-thiones
Kruithof, A.; Ploeger, M. L.; Janssen, E.; Helliwell, M.; de Kanter, F. J.; Ruijter, E.; Orru, R. V. A. Molecules 2012, 17, 1675-1685.
51. Recent Advances in Palladium-Catalyzed Cascade Cyclizations
Vlaar, T.; Ruijter, E.; Orru, R. V. A. Adv. Synth. Catal. 2011, 353, 809–841.
50. Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity
Ruijter, E.; Scheffelaar, R.; Orru, R. V. A. Angew. Chem. Int. Ed. 2011, 50, 6234–624.
49. Microwave-Assisted Multicomponent Reactions in the Synthesis of Heterocycles
Kruithof, A.; Ruijter, E.; Orru, R. V. A. Curr. Org. Chem. 2011, 15, 204-236.
48. Microbial-catalysed resolution of sterically demanding cyanohydrins
Paravidino, M.; Holt, J.; Romano, D.; Singh, N.; Arends, I. W.; Minnaard, A. J.; Orru, R. V. A.; Molinari, F.; Hanefeld, U. J. Mol. Catal. 2010, 63, 87–92.
47. Hydroxynitrile Lyase from Arabidopsis thaliana: Identification of Reaction Parameters for Enantiopure Cyanohydrin Synthesis by Pure and Immobilized Catalyst
Okrob, D.; Paravidino, M.; Orru, R. V. A.; Wiechert, W.; Hanefeld, U.; Pohl, M. Adv. Synth. Catal. 2011, 353, 2399–2408.
46. A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines
Coffinier, D.; El Kaim, L.; Grimaud, L.; Ruijter, E.; Orru, R. V. A. Tetrahedron Lett. 2011, 52, 3023-3025.
45. A Microwave-Assisted Diastereoselective Multicomponent Reaction To Access Dibenzo[c,e]azepinones: Synthesis and Biological Evaluation
Mehta, V. P.; Modha, S. G.; Ruijter, E.; van Hecke, K.; van Meervelt, L.; Pannecouque, C.; Balzarini, J.; Orru, R. V. A.; van der Eycken, E. J. Org. Chem. 2011, 76, 2828-2839.
44. Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion
Vlaar, T.; Ruijter, E.; Znabett, A.; Janssen, E.; de Kanter, F. J.; Maes, B. U.; Orru, R. V. A. Org. Lett. 2011, 13, 6496–6499.
43. Synthesis of 4-aminoquinazolines by palladium-catalyzed intramolecular imidoylation of N-(2-bromoaryl)amidines
van Baelen, G. A.; Kuijer, S.; Rycek, L.; Sergeyev, S.; Janssen, E.; de Kanter, F. J.; Maes, B. U.; Ruijter, E.; Orru, R. V. A. Chem. Eur. J. 2011, 17, 15039–15044.
42. YidC is in involved in the biogenesis of the secreted autotransporter Hemoglobin Protease
Jong, W. S.; ten Hagen-Jongman, C. M.; Ruijter, E.; Orru, R. V. A.; Genevaux, P.; Luirink, S. J. Biol. Chem. 2010, 285, 39682-39690.
41. Scope and limitations of an efficient four-component reaction for dihydropyridin-2-ones
Scheffelaar, R.; Paravidino, M.; Znabet, A.; Schmitz, R. F.; de Kanter, F. J.; Lutz, M.; Spek, A. L.; Guerra, C. F.; Bickelhaupt, F. M.; Groen, M. B.; Ruijter, E.; Orru, R. V. A. J. Org. Chem. 2010, 75, 1723–1732.
40. Isocyanoacetate Derivatives: Synthesis, Reactivity, and Application
Gulevich, A. V.; Zhdanko, A. G.; Orru, R. V. A.; Nenajdenko, V. G. Chem. Rev. 2010, 110, 5235–5331.
39. Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions
Znabet, A.; Ruijter, E.; de Kanter, F. J.; Köhler, V.; Helliwell, M.; Turner, N. J.; Orru, R. V. A. Angew. Chem. Int. Ed. 2010, 49, 5289 –5292.
38. Finding Furfural Hydrogenation Catalysts via Predictive Modelling
Strassberger. Z.; Mooijman, M.; Ruijter, E.; Alberts, A. H.; Maldonado, A. G.; Orru, R. V. A.; Rothenberg, G. Adv. Synth. Catal. 2010, 352, 2201–2210.
37. An Enzymatic Toolbox for the Kinetic Resolution of 2-(Pyridin-x-yl)but-3-yn-2-ols and Tertiary Cyanohydrins
Nguyen, G.; Kourist, R.; Paravidino, M.; Hummel, A.; Rehdorf, J.; Orru, R. V. A.; Hanefeld, U.; Bornscheuer, T. Eur. J. Org. Chem. 2010, 2753–2758.
36. Activity and Enantioselectivity of the Hydroxynitrile Lyase MeHNL in Dry Organic Solvents
Paravidino, M.; Sorgedrager, M. J.; Orru, R. V. A.; Hanefeld, U. Chem. Eur. J. 2010, 16, 7596–7604.
35. A facile route to ruthenium-carbene complexes and their application in furfural hydrogenation
Strassberger, Z.; Mooijman, M.; Ruijter, E.; Alberts, A. H.; de Graaff, C.; Orru, R. V. A.; Rothenberg, G. Appl. Organometal. Chem. 2010, 24, 142–146.
34. Synthesis of polycyclic alkaloid-type compounds by an N -acyliminium Pictet-Spengler/diels-alder sequence
Ruijter, E.; Garcia-Hartjes, J.; Hoffmann, F.; Vanwandelen, L. T.; Dekanter, F. J.; Janssen, E.; Orru, R. V. A. Synlett 2010, 16, 2485–2489.
33. Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence
Znabet, A.; Zonneveld, J.; Janssen, E.; De Kanter, F. J.; Helliwell, M.; Turner, N. J.; Ruijter, E.; Orru, R. V. A. Chem. Commun. 2010, 46, 7706-7708.
32. A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions
Znabet, A.; Polak, M. M.; Janssen, E.; de Kanter, F. J.; Turner, N. J.; Orru, R. V. A.; Ruijter, E. Chem. Commun. 2010, 46, 7918-7920.
31. Synthesis of Conformationally Constrained Peptidomimetics using Multicomponent Reactions
Scheffelaar, R.; Nijenhuis, R. A.; Paravidino, M.; Lutz, M.; Spek, A. L.; Ehlers, A. W.; de Kanter, F. J.; Groen, M. B.; Orru R. V. A.; Ruijter, E. J. Org. Chem. 2009, 74, 660-668.
30. High-Throughput Reaction Optimisation and Activity Screening of Ferrocene-Based Lewis Acid-Catalyst Complexes by Using Continuous-Flow Reaction Detection Mass Spectrometry
Martha, C. T.; Heemskerk, A.; Hoogendoorn, J. C.; Elders, N.; Niessen, W. M.; Orru, R. V. A.; Irth, H. Chem. Eur. J. 2009, 15, 7368–7375.
29. A Novel Three-Component Reaction toward Dihydrooxazolopyridines
Scheffelaar, R.; Paravidino, M.; Muilwijk, D.; Lutz, M.; Spek, A. L.; de Kanter, F. J.; Orru, R. V. A.; Ruijter, E. Org. Lett. 2009, 11, 125–128.
28. A multicomponent reaction towards N-(cyanomethyl)amides
Elders, N.; Ruijter, E.; de Kanter, F. J.; Janssen, E.; Lutz, M.; Spek, A. L.; Orru, R. V. A. Chem. Eur. J. 2009, 15, 6096 – 6099.
27. The efficient one-pot reaction of up to eight components by the union of multicomponent reactions
Elders, N.; van der Born, D.; Hendrickx, L. J.; Timmer, B. J.; Krause, A.; Janssen, E.; de Kanter, F. J.; Ruijter, E.; Orru, R. V. A. Angew. Chem. Int. Ed. 2009, 48, 5856–5859.
26. Synthesis of 3′-deoxyribolactones using a hydrolysis-induced lactonization cascade reaction of epoxy cyanohydrins
Vugts, D. J.; Aktas, H.; Al-Mafraji, K.; de Kanter, F. J.; Ruijter, E.; Groen, M. B.; Orru, R. V. A. Eur. J. Org. Chem. 2008, 1336–1339.
25. Selective formation of 2-imidazolines and 2-substituted oxazoles by using a three-component reaction
Elders, N.; Ruijter, E.; de Kanter, F. J.; Groen, M. B.; Orru, R. V. A. Chem. Eur. J. 2008, 14, 4961–4973.
24. Online screening of homogeneous catalyst performance using reaction detection mass spectrometry
Martha, C. T.; Elders, N.; Krabbe, J. G.; Kool, J.; Niessen, W. M.; Orru, R. V. A.; Irth, H. Anal. Chem. 2008, 80, 7121–7127.
23. Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones
Groenendaal, B.; Ruijter, E.; de Kanter, F. J.; Lutz, M.; Spek, A. L.; Orru, R. V. A. Org. Biomol. Chem. 2008, 6, 3158-3165.
22. Efficient C2 functionalisation of 2H-2-imidazolines
Bon, R. S.; Sprenkels, N. E.; Koningstein, M. M.; Schmitz, R. F.; de Kanter, F. J.; Domling, A.; Groen, M. B.; Orru, R. V. A.
21. A Multicomponent Synthesis of Triazinane Diones
Groenendaal, B.; Vugts, D. J.; Schmitz, R. F.; de Kanter, F. J.; Ruijter, E.; Groen, M. B.; Orru, R. V. A. J. Org. Chem. 2008, 73, 719–722.
20. 1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocycles
Groenendaal, B.; Ruijter, E.; Orru, R. V. A. Chem. Commun. 2008, 5474-5489.
19. Multicomponent Synthesis of N-Heterocyclic Carbene Complexes
Bon, R. S.; de Kanter, F. J.; Lutz, M.; Spek, A. L.; Jahnke, M. C.; Hahn, F. E.; Groen, M. B.; Orru, R. V. A. Organometallics 2007, 26, 3639–3650.
18. Multicomponent Synthesis of N-Heterocyclic Carbene Complexes
Bon, R. S.; de Kanter, F. J.; Lutz, M.; Spek, A. L.; Jahnke, M. C.; Hahn, F. E.; Groen, M. B.; Orru, R. V. A. Organometallics 2007, 26, 3639–3650.
17. A Flexible Six-Component Reaction To Access Constrained Depsipeptides Based on a Dihydropyridinone Core
Paravidino, M.; Scheffelaar, R.; Schmitz, R. F.; de Kanter, F. J.; Groen, M. B.; Ruijter, E.; Orru, R. V. A.
16. Rapid Combinatorial Access to Macrocyclic Ansa-peptoids and Peptides with a Natural Product Like Core Structure
de Greef, M.; Abeln, S.; Belkasmi, K.; Dömling, A.; Orru, R. V. A.; Wessjohann, L. A. Synthesis 2006, 23, 3997-4004.
15. Multicomponent synthesis of dihydropyrimidines and thiazines
Vugts, D. J.; Koningstein, M. M.; Schmitz, R. F.; de Kanter, F. J.; Groen, M. B.; Orru, R. V. A. Chem. Eur. J. 2006, 12, 7178–7189.
14. Microwave-Assisted Dimroth Rearrangement of Thiazines toDihydropyrimidinethiones: Synthetic and Mechanistic Aspects
Glasnov, T. N.; Vugts, D. J.; Koningstein, M. M.; Desai, B.; Fabian, W. M.; Orru, R. V. A.; Kappe, C. O. QSAR Comb. Sci. 2006, 25, 509–518.
13. MCRs and Related Chemistry
Orru, R. V. A. QSAR Comb. Sci. 2006, 25, 421-421.
12. Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation
Gelens, E.; De Kanter, F. J.; Schmitz, R. F.; Sliedregt, L. A.; Van Steen, B. J.; Kruse, C. G.; Leurs, R.; Groen, M. B.; Orru, R. V. A. Mol. Divers. 2006, 10, 17–22.
11. Dye-modified and Photoswitchable Macrocycles by Multiple Multicomponent Macrocyclizations Including Bifunctional BuildingBlocks (MiBs)
Kreye, O.; Westermann, B.; Rivera, D. G.; Johnson, D. V.; Orru, R. V. A.; Wessjohann, L. A. QSAR Comb. Sci. 2006, 25, 461– 464.
10. Diastereoselective Multicomponent Synthesis of Dihydropyridones with an Isocyanide Functionality
Paravidino, M.; Bon, R. S.; Scheffelaar, R.; Vugts, D. J.; Znabet, A.; Schmitz, R. F.; de Kanter, F. J.; Lutz, M.; Spek, A. L.; Groen, M. B.; Orru, R. V. A. Org. Lett. 2006, 8, 5369–5372.
9. Continuous Synthesis of Tri- and Tetrasubstituted Imidazoles via a Multicomponent Reaction under Microreactor Conditions
Acke, D. R.; Orru, R. V. A.; Stevens, C. V. QSAR Comb. Sci. 2006, 25, 474–483.
8. An atom efficient and solvent-free synthesis of structurally diverse amides using microwave
Gelens, E.; Smeets, L.; Sliedregt, L. A.; van Steen, B. J.; Kruse, C. G.; Leurs, R.; Orru, R. V. A. Tetrahedron Lett. 2005, 46, 3751-3754.
7. Multicomponent synthesis of 2-imidazolines
Bon, R. S.; van Vliet, B.; Sprenkels, N. E.; Schmitz, R. F.; de Kanter, F. J. J.; Stevens, C. V.; Swart, M.; Bickelhaupt, F. M.; Groen, M. B.; Orru, R. V. A. J. Org. Chem. 2005, 70, 3542–3553.
6. A new route to protected acyloins and their enzymatic resolution with lipases
Scheid, G. O.; Kuit, W.; Ruijter, E.; Orru, R. V. A.; Henke, E.; Bornscheuer, U.; Wessjohann, L. A. Eur. J. Org. Chem. 2004, 1063-1074.
5. Recent advances in solution-phase multicomponent methodology for the synthesis of heterocyclic compounds
Orru R. V. A.; de Greef, M. Synthesis 2003, 10, 1471-1499.
4. Novel Multicomponent Reaction for the Combinatorial Synthesis 0f 2-Imidazolines
Bon, R. S.; Hong, C.; Bouma, M. J.; Schmitz, R. F.; De Kanter, F. J.; Lutz, M.; Spek, A. L.; Orru, R. V. A. Org. Lett. 2003, 5, 3759–3762
3. A novel four-component reaction for the synthesis of functionalised dihydropyrimidines
Vugts, D. J.; Jansen, H.; Schmitz, R. F.; de Kanter, F. J.; Orru, R. V. A. Chem. Commun. 2003, 2594-2595.
2. A biomimetic approach towards the stereoselective synthesis of acetogenins
Orru, R. V. A., de Greef, M.; van Heijst, J.; Hunting, M.; Wessling, C.; Schmitz, R. F. Pure Appl. Chem. 2003, 75, 259–264.
1. In Situ Formation of Allyl Ketones via Hiyama-Nozaki Reactions Followed by a Chromium-Mediated Oppenauer Oxidation
Schrekker, H. S.; de Bolster, M. W.; Orru, R. V. A.; Wessjohann, L. A. J. Org. Chem. 2002, 67, 1975–1981.
